At present, common linkers can be mainly divided into two categories according to the cleavage method: chemical cleavage and enzymatic cleavage. 1. Chemical cracking linker
With the rapid development of modern economy, people’s quality of life has been significantly improved, and the corresponding demand has also increased, one of which
1 Introduction First, a brief introduction to the composition of ADC drugs, antibody-drug conjugates, as the name suggests, includes 3 partial antibodies, drugs (also known
Molecularly targeted drugs mainly target the key targets of the pathophysiological occurrence and development of malignant tumors for therapeutic intervention, and some molecularly targeted drugs
The birth of “AILH Dual-Cause Targeted Therapy” is the result of ten years of dedicated research and continuous transformation of scientific research results into clinical
The design of clinically successful ADCs depends not only on the potency of the payload and its point of attachment, linker stability, and efficient drug
Alcoholic liver disease (ALD) is a common chronic liver disease that often leads to cirrhosis. With the rising incidence, alcoholic liver disease has become the
1. Q: What should I do if I want to reuse the ultrafiltration tube provided in the coupling kit?answer:Use a pipette tip to absorb a
The main content of preclinical toxicology research is the safety evaluation of drugs. Whether the drug is safe and effective is the determining factor for
Antibody-drug conjugates (ADCs) are the coupling of cytotoxic small-molecule drugs to targeted monoclonal antibodies through ADC linkers, which can reduce the toxicity of small-molecule drugs
Cytotoxicity is a key factor determining the lethality of ADC drugs. An ideal cytotoxin should have the following properties: Highly toxic: Usually moderately toxic cytotoxic
With the continuous increase in R&D investment of global pharmaceutical companies, the competition in the global pharmaceutical market has become increasingly fierce. Enterprises are increasing
