The transcription factor family consists of c-MYC, L-MYC and N-MYC, which are the main regulators of cellular processes such as cell proliferation, cell differentiation, cell
Protein-polymer conjugates are widely used as disease therapeutics and have advantages such as high target specificity. but their use also faces some challenges: rapid clearance
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent mechanism of cytotoxicity, mainly mediated by natural killer (NK) cells. When specific antibodies bind to the targeted cell
Antibodies of ADC drugs are antibodies targeting tumor cell antigens, which are linked to small-molecule drug poisons through linkers to kill tumor cells and surrounding
Antibody-drug conjugate (ADC) therapy has developed rapidly in recent decades. Currently, 14 products have been approved worldwide and more than 140 ADCs are in clinical
Foreword The mucin (MUC) family is a group of highly glycosylated macromolecules that are abundantly expressed in mammalian epithelial cells. Mucins contribute to the formation
Foreword Chimeric antigen receptor (CARs)-based T-cell therapy has shown great success against blood cancers; however, potential lethal toxicity (eg, cytokine release syndrome) and high cost
On October 14, a study titled “Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast
The protein component of the biological product from the production cell line itself is called host cell protein (HCP). HCPs are complex in composition, including
In a new study, an international team has identified 89 genetic loci associated with stroke risk and six genes that are potential drug targets for
As an important component of current COVID-19 mRNA vaccines, lipid nanoparticles (LNPs) play a key role in effectively protecting mRNA and transporting it to cells.
Antibody drug conjugates (ADCs) are complex molecules in which monoclonal antibodies and cytotoxic drugs (small molecule payloads) are linked by linkers to form conjugates. In
